Suprax: Potent Cephalosporin for Effective Bacterial Infection Treatment
Suprax
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| Product dosage: 200mg | |||
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Synonyms | |||
Suprax (cefixime) is a third-generation oral cephalosporin antibiotic designed to target a broad spectrum of gram-positive and gram-negative bacteria. It is widely prescribed for respiratory, urinary tract, and ear infections due to its reliable bactericidal activity and favorable pharmacokinetic profile. With high bioavailability and once-daily dosing convenience, Suprax offers clinicians a trusted option for outpatient management of common bacterial pathogens, including those resistant to earlier-generation antibiotics.
Features
- Active ingredient: cefixime
- Available as 400 mg tablets and 100 mg/5 mL oral suspension
- Third-generation cephalosporin antibiotic
- Broad-spectrum activity against β-lactamase-producing strains
- Once-daily dosing regimen
- High oral bioavailability (~40-50%)
- FDA-approved for multiple indications
Benefits
- Effectively eradicates susceptible bacterial infections with a concise treatment course
- Minimizes dosing frequency to enhance patient adherence and convenience
- Demonstrates reliable coverage against common community-acquired pathogens
- Offers a well-tolerated alternative for patients with penicillin allergies (with appropriate caution)
- Reduces risk of resistance development compared to narrower-spectrum agents when used appropriately
- Provides flexible formulation options suitable for both adults and pediatric patients
Common use
Suprax is indicated for the treatment of mild to moderate infections caused by susceptible strains of designated microorganisms. Common uses include acute bacterial exacerbations of chronic bronchitis due to Streptococcus pneumoniae and Haemophilus influenzae, uncomplicated urinary tract infections caused by Escherichia coli and Proteus mirabilis, otitis media caused by H. influenzae, Moraxella catarrhalis, and S. pyogenes, and uncomplicated gonorrhea caused by Neisseria gonorrhoeae. It is also used for pharyngitis and tonsillitis caused by S. pyogenes.
Dosage and direction
Adults: The recommended adult dose is 400 mg daily, administered as a single dose or in two divided doses. For uncomplicated gonorrhea, a single 400 mg dose is recommended.
Pediatric patients: The recommended dose for children is 8 mg/kg/day administered either as a single daily dose or in two divided doses. For children weighing more than 50 kg or older than 12 years, the adult dose should be used.
Renal impairment: For patients with creatinine clearance less than 60 mL/min, the dose should be reduced by 25-50%. For those on continuous ambulatory peritoneal dialysis or hemodialysis, supplemental dosing may be necessary.
Suprax may be taken without regard to meals, though absorption is enhanced when taken with food. The suspension form should be shaken well before each use.
Precautions
- Use with caution in patients with history of gastrointestinal disease, particularly colitis
- Prolonged use may result in overgrowth of nonsusceptible organisms
- Should be prescribed with caution to patients with history of hypersensitivity reactions to cephalosporins, penicillins, or other drugs
- May cause false-positive reactions for glucose in the urine with Benedict’s or Fehling’s solutions
- Use during pregnancy only if clearly needed (Pregnancy Category B)
- Exercise caution when administering to nursing mothers
- Superinfection with fungi or other pathogens may occur
Contraindications
- Known hypersensitivity to cefixime, any cephalosporin, or any component of the formulation
- History of severe hypersensitivity reactions (anaphylaxis) to any β-lactam antibiotic
- Not recommended for patients with known phenylketonuria (tablets contain aspartame)
Possible side effect
Common adverse reactions (≥1%) include:
- Diarrhea (16%)
- Loose stools (6%)
- Abdominal pain (3%)
- Nausea (7%)
- Dyspepsia (3%)
- Flatulence (4%)
- Headache (2%)
- Dizziness (1%)
Less common but serious side effects may include:
- Pseudomembranous colitis
- Allergic reactions (rash, urticaria, pruritus)
- Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis)
- Hematologic effects (eosinophilia, thrombocytopenia, neutropenia)
- Hepatic transaminase elevations
- Interstitial nephritis
- Seizures (particularly in patients with renal impairment)
Drug interaction
- Probenecid: May increase and prolong cefixime blood levels
- Carbamazepine: May increase carbamazepine levels
- Warfarin: May potentiate anticoagulant effect
- Oral contraceptives: May reduce contraceptive effectiveness (recommend additional contraception)
- Chloramphenicol: Antagonistic effect in vitro
- Nephrotoxic drugs: May increase risk of renal toxicity
Missed dose
If a dose is missed, it should be taken as soon as remembered. However, if it is almost time for the next dose, the missed dose should be skipped and the regular dosing schedule resumed. Patients should not double the dose to make up for a missed dose.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric distress, diarrhea, and convulsions. Gastric lavage may be indicated, but hemodialysis or peritoneal dialysis may not be effective in significantly removing cefixime from the body. Serum levels should be monitored, and supportive measures should be implemented.
Storage
- Tablets: Store at 20-25°C (68-77°F) in a tight container
- Oral suspension: Store powder at room temperature before reconstitution
- After reconstitution: Store in refrigerator (2-8°C/36-46°F) and discard after 14 days
- Protect from light and moisture
- Keep out of reach of children
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Suprax is a prescription medication that should only be used under the supervision of a qualified healthcare professional. Always follow your healthcare provider’s instructions regarding dosage and administration. Do not use this medication for conditions for which it was not prescribed. Report any adverse reactions to your healthcare provider immediately.
Reviews
Clinical studies demonstrate that Suprax achieves clinical cure rates of 85-95% for approved indications. In comparative trials, it has shown efficacy comparable to other oral cephalosporins with the advantage of once-daily dosing. Pediatric studies indicate similar efficacy and safety profiles to amoxicillin-clavulanate for otitis media. Patient satisfaction surveys report high adherence rates due to the convenient dosing schedule and generally favorable side effect profile compared to some alternative antibiotics.