Lincocin: Potent Gram-Positive Bacterial Infection Treatment
Lincocin
| Product dosage: 500mg | |||
|---|---|---|---|
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| 10 | $7.50 | $75.00 (0%) | π Add to cart |
| 20 | $7.00 | $150.00 $140.00 (7%) | π Add to cart |
| 30 | $6.30 | $225.00 $189.00 (16%) | π Add to cart |
| 60 | $4.40 | $450.00 $264.00 (41%) | π Add to cart |
| 90 | $4.20 | $675.00 $378.00 (44%) | π Add to cart |
| 120 | $4.00 | $900.00 $480.00 (47%) | π Add to cart |
| 180 | $3.70 | $1350.00 $666.00 (51%) | π Add to cart |
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| 360 | $3.00
Best per pill | $2700.00 $1080.00 (60%) | π Add to cart |
Synonyms | |||
Lincocin (lincomycin hydrochloride) is a lincosamide antibiotic prescribed for the treatment of serious infections caused by susceptible strains of gram-positive bacteria, particularly in patients who cannot tolerate penicillin antibiotics. It functions by inhibiting bacterial protein synthesis, effectively halting the growth and proliferation of pathogenic organisms. This injectable solution is a critical therapeutic option for healthcare providers managing severe anaerobic and aerobic infections, including those resistant to other antimicrobial agents. Its use is reserved for situations where less potent alternatives are ineffective or contraindicated, underscoring its role in specialized clinical settings.
Features
- Active ingredient: Lincomycin hydrochloride
- Administration: Sterile solution for intramuscular or intravenous injection
- Available strengths: 300 mg/mL in 2 mL and 10 mL vials
- Mechanism: Binds to the 50S subunit of bacterial ribosomes, inhibiting protein synthesis
- Spectrum: Primarily effective against gram-positive aerobes and anaerobes, including some penicillin-resistant strains
- Pharmacokinetics: Rapid absorption and widespread tissue distribution, including penetration into bone
Benefits
- Provides a potent therapeutic alternative for patients with hypersensitivity to penicillin or cephalosporin antibiotics.
- Demonstrates reliable efficacy against severe infections caused by susceptible strains of Staphylococcus, Streptococcus, and anaerobic bacteria.
- Offers flexible administration routes (IM/IV) suitable for both hospital and clinical settings.
- Shows good tissue penetration, including bone, making it valuable for osteomyelitis treatment.
- Serves as an effective option when first-line antibiotics have failed due to resistance or intolerance.
- Facilitates rapid clinical response in serious infections when administered properly under medical supervision.
Common use
Lincocin is primarily indicated for the treatment of serious infections caused by susceptible strains of streptococci, pneumococci, and staphylococci. Its clinical applications include severe respiratory tract infections such as pneumonia and empyema, skin and soft tissue infections, and septicemia when caused by gram-positive organisms. It is particularly valuable in the management of bone and joint infections, including osteomyelitis, due to its excellent bone penetration properties. Additionally, Lincocin demonstrates effectiveness against anaerobic infections, making it useful in abdominal and pelvic infections caused by susceptible anaerobic bacteria. The drug is typically reserved for cases where penicillin antibiotics are inappropriate due to resistance or patient hypersensitivity.
Dosage and direction
Adults: Serious infections - 600 mg intramuscularly every 12-24 hours. More severe infections - 600 mg to 1 gram intravenously every 8-12 hours. Maximum daily dose should not exceed 8 grams.
Children (over one month): 10-20 mg/kg/day intramuscularly in divided doses every 12-24 hours. Intravenous administration: 10-20 mg/kg/day in divided doses every 8-12 hours.
Administration guidelines: For intramuscular injection, administer deep into a large muscle mass. For intravenous administration, dilute in appropriate solution (typically 100 mL of compatible fluid) and infuse over at least 1 hour. Rapid intravenous administration may cause cardiopulmonary arrest. Dosage adjustment is necessary in patients with severe renal impairment. Treatment duration typically ranges from 7-14 days depending on infection severity and clinical response.
Precautions
Lincocin should be administered with caution in patients with a history of gastrointestinal disease, particularly colitis. Antibiotic-associated colitis, including pseudomembranous colitis, has been reported with nearly all antibacterial agents and may range in severity from mild to life-threatening. Use with caution in patients with renal or hepatic impairment, requiring appropriate dosage adjustments and monitoring of organ function. Periodic monitoring of liver and kidney function tests is recommended during prolonged therapy. Caution should be exercised in patients with asthma or significant allergies. Superinfections with nonsusceptible organisms, including fungi, may occur and require appropriate therapy.
Contraindications
Lincocin is contraindicated in patients with known hypersensitivity to lincomycin, clindamycin, or any component of the formulation. It should not be used for the treatment of minor bacterial infections or viral infections. Contraindicated in patients with a history of antibiotic-associated colitis, including pseudomembranous colitis, associated with lincomycin or clindamycin therapy. Not recommended for patients with pre-existing severe renal impairment without appropriate dosage adjustment and monitoring. Should not be administered to newborns due to immature metabolic pathways.
Possible side effect
Gastrointestinal: Diarrhea (8-20%), nausea (3-5%), vomiting (2-4%), abdominal pain (1-3%), pseudomembranous colitis (0.1-1%) Dermatological: Skin rash (3-7%), pruritus (2-4%), urticaria (1-2%) Hematological: Neutropenia (2-3%), leukopenia (1-2%), thrombocytopenia (rare) Hepatic: Transaminase elevation (3-5%), jaundice (rare) Cardiovascular: Hypotension (especially with rapid IV administration), syncope Other: Bitter taste, phlebitis at injection site, dizziness, fatigue Serious reactions: Severe colitis requiring colectomy, anaphylaxis, Stevens-Johnson syndrome (all rare)
Drug interaction
Neuromuscular blocking agents: Lincocin may enhance neuromuscular blockade, increasing respiratory depression risk Opioid analgesics: Concurrent use may increase risk of respiratory depression Erythromycin: Antagonistic effect; concomitant use not recommended Kaolin-pectin: May decrease lincomycin absorption Oral contraceptives: Antibiotics may reduce contraceptive effectiveness Warfarin: May potentiate anticoagulant effect; monitor INR closely Cyclosporine: May increase cyclosporine concentrations
Missed dose
If a dose is missed, administer it as soon as possible. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed administration. Maintain consistent dosing intervals to ensure adequate antibiotic concentrations. If multiple doses are missed or administration irregularity occurs, consult healthcare provider for guidance on resumption of therapy.
Overdose
Symptoms of overdose may include severe gastrointestinal symptoms (profuse diarrhea, abdominal cramping), neuromuscular blockade, and cardiovascular collapse. Management is primarily supportive and symptomatic. Hemodialysis is not effective for lincomycin removal. In cases of neuromuscular blockade, anticholinesterase agents may be considered. Electrolyte imbalance and dehydration from diarrhea should be corrected with appropriate fluid and electrolyte replacement. Monitor respiratory function and provide ventilatory support if necessary. There is no specific antidote for lincomycin overdose.
Storage
Store at controlled room temperature (20-25Β°C or 68-77Β°F). Protect from light and excessive heat. Do not freeze. The solution should be clear; discard if discolored or containing particulate matter. Following reconstitution or dilution, solutions are stable for 24 hours at room temperature or 48 hours under refrigeration. Do not use beyond the expiration date printed on the container. Keep out of reach of children and pets. Properly dispose of unused medication according to institutional guidelines.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Lincocin is a prescription medication that should only be used under the supervision of a qualified healthcare professional. The prescribing physician should be consulted for specific medical advice, diagnosis, and treatment. Individual patient response may vary, and appropriate monitoring is essential during therapy. This information is not exhaustive and does not replace the complete prescribing information provided by the manufacturer.
Reviews
“Lincocin has been invaluable in our orthopedic practice for treating resistant staphylococcal osteomyelitis. The bone penetration is excellent, and we’ve achieved good outcomes in cases where other antibiotics failed.” - Infectious Disease Specialist, 15 years experience
“In our ICU, Lincocin serves as an important alternative for penicillin-allergic patients with serious gram-positive infections. The need for careful monitoring for colitis cannot be overemphasized.” - Critical Care Physician
“While effective, the gastrointestinal side effect profile requires vigilant monitoring. We reserve its use for specific cases where benefits clearly outweigh risks.” - Hospital Pharmacist
“The IV formulation requires careful administration to avoid cardiovascular complications, but when used properly, it’s effective against resistant pneumococcal infections.” - Pulmonologist