Levoquin

Levoquin is used to treat infections of the lower respiratory tract, urinary tract, kidneys, skin, soft tissues, chronic bronchitis, acute sinusitis, chronic bacterial prostatitis and tuberculosis.

Product dosage: 250mg
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270	$0.90	$459.00 $243.00 (47%)	🛒 Add to cart
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Product dosage: 500mg
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30	$1.90	$60.00 $57.00 (5%)	🛒 Add to cart
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90	$1.64	$180.00 $148.00 (18%)	🛒 Add to cart
120	$1.50	$240.00 $180.00 (25%)	🛒 Add to cart
180	$1.25	$360.00 $225.00 (38%)	🛒 Add to cart
270	$1.13	$540.00 $305.00 (44%)	🛒 Add to cart
360	$1.03 Best per pill	$720.00 $370.00 (49%)	🛒 Add to cart

Levoquin (levofloxacin) is a broad-spectrum fluoroquinolone antibiotic designed to treat a wide range of bacterial infections with high efficacy and systemic penetration. As a third-generation quinolone, it demonstrates superior activity against both Gram-positive and Gram-negative pathogens, including resistant strains. Its once-daily dosing regimen supports patient compliance while maintaining therapeutic concentrations throughout treatment courses. Clinicians rely on Levoquin for its proven clinical success in respiratory, urinary, skin, and complicated intra-abdominal infections.

Features

• Active ingredient: Levofloxacin (hemihydrate)
• Available in 250mg, 500mg, and 750mg oral tablets and injection solution
• Broad-spectrum activity covering aerobic Gram-positive and Gram-negative bacteria
• High oral bioavailability (>99%) with rapid absorption
• Penetrates effectively into tissues, fluids, and phagocytes
• Once-daily dosing supported by prolonged half-life (6–8 hours)

Benefits

• Rapid bactericidal action through inhibition of bacterial DNA gyrase and topoisomerase IV
• High clinical cure rates in community-acquired and hospital-acquired infections
• Convenient dosing schedule improves adherence and reduces treatment failure
• Effective against many antibiotic-resistant pathogens including some MRSA and Pseudomonas strains
• Well-established safety profile with extensive clinical use since 1996
• Available in both IV and oral formulations allowing for seamless transition therapy

Common use

Levoquin is indicated for the treatment of adults with infections caused by susceptible strains of designated microorganisms, including:

• Community-acquired pneumonia (including multidrug-resistant strains)
• Complicated and uncomplicated urinary tract infections
• Acute bacterial exacerbation of chronic bronchitis
• Acute bacterial sinusitis
• Skin and skin structure infections
• Chronic bacterial prostatitis
• Complicated intra-abdominal infections (with metronidazole)
• Inhalational anthrax (post-exposure)

Dosage and direction

Dosage varies based on infection type, severity, renal function, and pathogen susceptibility. Typical adult doses:

• 250–750 mg orally or IV once every 24 hours
• Duration: 7–14 days (may extend to 28 days for chronic prostatitis)
• Administer with a full glass of water; may be taken with or without food
• Maintain adequate hydration during treatment
• Dosage adjustment required for patients with creatinine clearance <50 mL/min
• Complete full course of therapy even if symptoms improve earlier

Precautions

• Tendon inflammation or rupture may occur during or after treatment (risk increases with age >60, corticosteroid use, organ transplantation)
• May exacerbate muscle weakness in patients with myasthenia gravis
• Peripheral neuropathy (irreversible in some cases) has been reported
• CNS effects including seizures, dizziness, and confusion may occur
• Photosensitivity reactions possible; avoid excessive sunlight/UV exposure
• Clostridium difficile-associated diarrhea reported (may range from mild to fatal colitis)
• Regular renal function monitoring advised during extended therapy

Contraindications

• Known hypersensitivity to levofloxacin, other quinolones, or product components
• History of tendon disorders related to fluoroquinolone administration
• Patients with myasthenia gravis (may exacerbate muscle weakness)
• Concurrent administration with tizanidine (contraindicated due to interaction)
• Pediatric patients (except for inhalational anthrax post-exposure)
• Pregnancy (Category C: use only if potential benefit justifies potential risk)

Possible side effect

Common (≥1%):

• Nausea (3–7%)
• Diarrhea (3–6%)
• Headache (3–6%)
• Constipation (2–4%)
• Dizziness (2–3%)

Serious (<1% but require immediate medical attention):

• Tendon rupture (Achilles most common)
• Peripheral neuropathy
• CNS effects (seizures, psychosis, increased intracranial pressure)
• QT prolongation and arrhythmias
• Hepatotoxicity (elevated transaminases, hepatitis)
• Blood dyscrasias (neutropenia, thrombocytopenia)
• Severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis)
• Hypersensitivity reactions (anaphylaxis, angioedema)

Drug interaction

Significant interactions include:

• Antacids containing magnesium/aluminum, sucralfate, iron, zinc: reduce absorption (administer Levoquin 2 hours before or 4 hours after)
• Warfarin: enhanced anticoagulant effect (monitor INR closely)
• NSAIDs: increased risk of CNS stimulation and seizures
• Antiarrhythmics (Class IA, III): additive QT prolongation
• Corticosteroids: increased risk of tendon rupture
• Theophylline: increased theophylline concentrations
• Cyclosporine: elevated serum creatinine
• Oral hypoglycemics: may enhance hypoglycemic effect

Missed dose

• Take the missed dose as soon as remembered
• If almost time for next dose, skip missed dose and resume regular schedule
• Do not double doses to make up for missed dose
• Contact healthcare provider if multiple doses missed or uncertainty about scheduling

Overdose

Symptoms may include: CNS excitation (seizures, confusion), QT prolongation, gastrointestinal distress. Management involves:

• Symptomatic and supportive care
• ECG monitoring for QT prolongation
• Hemodialysis removes approximately 10–20% of dose
• No specific antidote available
• Contact poison control center (1-800-222-1222) for latest guidance

Storage

• Store at 20–25°C (68–77°F); excursions permitted to 15–30°C (59–86°F)
• Protect from light and excessive moisture
• Keep in original container with lid tightly closed
• Do not transfer to other containers
• Keep out of reach of children and pets
• Properly dispose of unused or expired medication

Disclaimer

This information is for educational purposes and does not replace professional medical advice. Dosage and treatment decisions must be made by qualified healthcare providers based on individual patient characteristics. The prescriber should consult complete prescribing information for details. Serious adverse reactions may occur even with proper use. Patients should report any unusual symptoms to their healthcare provider immediately.

Reviews

“Levoquin remains a cornerstone in our antimicrobial arsenal for resistant respiratory infections. The once-daily dosing significantly improves compliance in outpatient therapy.” – Infectious Disease Specialist, 15 years experience

“While effective, we reserve levofloxacin for cases where alternatives are inappropriate due to the black box warnings. Appropriate patient selection is critical.” – Hospital Pharmacist

“After failing with first-line antibiotics, Levoquin cleared my pneumonia within 72 hours. The convenience of once-daily dosing made the 10-day course manageable despite mild nausea.” – Patient with multidrug-resistant pneumonia