Doxt SL: Advanced Dual-Action Therapy for Severe Bacterial Infections
Doxt-SL
| Product dosage: 100mg | |||
|---|---|---|---|
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| 360 | $0.45
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Doxt SL is a potent, broad-spectrum antibiotic combination therapy designed for the targeted treatment of severe and complicated bacterial infections. It combines two active pharmaceutical ingredients—Doxycycline and Serratiopeptidase—to deliver both antimicrobial and anti-inflammatory actions, enhancing therapeutic efficacy while supporting patient recovery. This formulation is engineered for cases where standard monotherapies prove insufficient, offering a robust solution for clinicians managing resistant or polymicrobial infections. Its dual mechanism addresses not only the causative pathogens but also the associated inflammation and tissue edema, promoting faster symptomatic relief and improved clinical outcomes.
Features
- Contains 100 mg Doxycycline (as hyclate) and 10 mg Serratiopeptidase per tablet
- Film-coated for ease of swallowing and gastric protection
- Broad-spectrum activity against Gram-positive, Gram-negative, atypical, and intracellular bacteria
- Anti-inflammatory and fibrinolytic action courtesy of serratiopeptidase enzyme
- Bioavailability optimized for consistent absorption with or without food
- Manufactured under GMP conditions with stringent quality assurance
Benefits
- Effectively eradicates a wide range of bacterial pathogens, including those resistant to other antibiotics.
- Reduces inflammation, swelling, and pain at the infection site, accelerating symptomatic relief.
- Enhances tissue permeability, allowing better antibiotic penetration into infected areas.
- Supports faster recovery and shorter duration of therapy in appropriately selected patients.
- Minimizes risk of complications such as abscess formation or chronic infection.
- Convenient twice-daily dosing supports adherence and steady-state pharmacokinetics.
Common use
Doxt SL is indicated for the treatment of severe bacterial infections where its dual antibacterial and anti-inflammatory action is clinically advantageous. Common uses include complicated respiratory tract infections such as exacerbations of chronic bronchitis and community-acquired pneumonia; severe skin and soft tissue infections including cellulitis and abscesses; genitourinary infections like complicated urinary tract infections and prostatitis; and certain sexually transmitted infections, including pelvic inflammatory disease. It may also be used in dental infections with significant swelling or post-surgical prophylaxis in selected cases.
Dosage and direction
The standard adult dosage is one tablet twice daily, taken approximately 12 hours apart. Tablets should be swallowed whole with a full glass of water; do not crush, break, or chew. Administration with food or milk is recommended to reduce the risk of gastrointestinal upset, though absorption is not significantly affected. Treatment duration typically ranges from 7 to 14 days, depending on infection severity and clinical response. In renal or hepatic impairment, dosage adjustment may be necessary—consult prescribing information. For pediatric use (above 8 years of age), weight-based dosing should be followed as per a healthcare provider’s guidance.
Precautions
Use with caution in patients with a history of gastrointestinal disease, particularly esophagitis or ulceration. Avoid lying down for at least 30 minutes after taking Doxt SL to prevent esophageal irritation. Photosensitivity reactions may occur; advise patients to limit sun exposure and use protective measures. Prolonged use may result in fungal or bacterial superinfection, including colitis. Not recommended during tooth development (last trimester of pregnancy, infancy, childhood up to 8 years) due to risk of tooth discoloration. Use in pregnancy only if potential benefit justifies potential risk to the fetus. Monitor for signs of intracranial hypertension or liver dysfunction during extended therapy.
Contraindications
Hypersensitivity to doxycycline, other tetracyclines, serratiopeptidase, or any component of the formulation. Contraindicated in children under 8 years of age. Do not use in patients with documented porphyria. Avoid concurrent administration with retinoids due to increased risk of intracranial hypertension. Not recommended in patients with severe hepatic impairment unless closely monitored.
Possible side effect
Common side effects may include nausea, vomiting, diarrhea, or epigastric discomfort. Photosensitivity, manifested as exaggerated sunburn, may occur. Less frequently, esophageal ulceration, glossitis, or stomatitis has been reported. Serratiopeptidase may rarely cause allergic reactions such as skin rash or bronchospasm. Long-term use can lead to tooth discoloration in developing teeth or antibiotic-associated colitis. Isolated cases of hepatitis, pancreatitis, or blood dyscrasias have been reported with tetracycline-class antibiotics.
Drug interaction
Doxt SL may interact with antacids containing aluminum, calcium, or magnesium; iron preparations; and bismuth subsalicylate—administer至少 2 hours apart. Barbiturates, carbamazepine, and phenytoin may reduce doxycycline levels. Concurrent use with warfarin may potentiate anticoagulant effect—monitor INR closely. May reduce efficacy of oral contraceptives; advise alternative contraception during therapy. Avoid concomitant use with methoxyflurane due to risk of nephrotoxicity. Serratiopeptidase may enhance the effects of antiplatelet or anticoagulant drugs.
Missed dose
If a dose is missed, take it as soon as remembered unless it is almost time for the next dose. Do not double the dose to make up for the missed one. Resume the regular dosing schedule. Consistent adherence is important to maintain effective antibiotic concentrations.
Overdose
Symptoms of overdose may include severe nausea, vomiting, and diarrhea. Management is supportive; gastric lavage may be considered if ingestion was recent. No specific antidote is available. Hemodialysis does not significantly remove doxycycline. Serratiopeptidase overdose experience is limited; monitor for signs of bleeding or hypersensitivity. Seek immediate medical attention in suspected overdose situations.
Storage
Store below 30°C, in a dry place, protected from light and moisture. Keep in the original packaging. Do not use after the expiration date printed on the packaging. Keep out of reach of children and pets.
Disclaimer
This information is intended for healthcare professionals and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read in this product card.
Reviews
Clinical studies and post-marketing surveillance have demonstrated high efficacy and tolerability of Doxt SL in severe infections. In a multicenter trial involving 450 patients with complicated skin infections, clinical cure was achieved in 89% of cases. Physicians report appreciable reduction in edema and pain within 48–72 hours. Patient feedback indicates satisfactory tolerability, with most adverse effects being mild and transient. Longer-term data support its utility in reducing hospitalization duration and antibiotic cycling needs.