Keftab: Effective Cephalexin Treatment for Bacterial Infections
Keftab
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| Product dosage: 250mg | |||
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| Product dosage: 375mg | |||
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| Product dosage: 500mg | |||
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Keftab is a branded oral antibiotic medication containing the active ingredient cephalexin, a first-generation cephalosporin antibiotic. It is prescribed for the treatment of a wide range of bacterial infections caused by susceptible strains of microorganisms. By inhibiting bacterial cell wall synthesis, Keftab provides bactericidal action, effectively eliminating pathogens and resolving infection-related symptoms. It is commonly utilized in both outpatient and inpatient settings due to its reliable efficacy and generally favorable safety profile when used as directed under medical supervision.
Features
- Contains cephalexin as the active pharmaceutical ingredient
- Available in 500 mg and 1 g tablet formulations
- Demonstrated in vitro activity against Gram-positive and some Gram-negative bacteria
- Oral administration with good gastrointestinal absorption
- Manufactured under strict pharmaceutical quality control standards
Benefits
- Rapid onset of antibacterial action to help control infection progression
- High clinical cure rates for indicated bacterial infections
- Convenient oral dosing regimen supports treatment adherence
- Generally well-tolerated profile with predictable pharmacokinetics
- Established safety data from decades of clinical use
- Effective against common pathogens causing respiratory, skin, and urinary tract infections
Common use
Keftab (cephalexin) is indicated for the treatment of infections caused by susceptible strains of designated microorganisms, including respiratory tract infections such as pneumonia and bronchitis caused by Streptococcus pneumoniae and other streptococci. It is also employed for skin and skin structure infections attributable to Staphylococcus aureus and/or Streptococcus pyogenes, bone infections caused by S. aureus and/or Proteus mirabilis, genitourinary tract infections including acute prostatitis caused by Escherichia coli, P. mirabilis, and Klebsiella pneumoniae, and otitis media caused by S. pneumoniae, Haemophilus influenzae, staphylococci, and streptococci. The medication demonstrates particular utility in outpatient management of mild to moderate community-acquired infections.
Dosage and direction
The dosage of Keftab varies according to the infection being treated, its severity, and the patient’s renal function. For adults, the usual dose is 250 mg every 6 hours, though more severe infections may require 500 mg every 6-12 hours. For streptococcal pharyngitis, skin and skin structure infections, and uncomplicated cystitis, the dosage is 500 mg every 12 hours. The maximum daily dose for adults is 4 grams. Pediatric dosing is typically based on weight at 25-50 mg/kg/day in divided doses, with more severe infections potentially requiring up to 100 mg/kg/day. Dosage adjustment is necessary in patients with impaired renal function. Keftab should be administered with food to minimize potential gastrointestinal upset. Complete the full course of therapy even if symptoms improve to prevent development of resistant bacteria.
Precautions
Before prescribing Keftab, carefully inquire about previous hypersensitivity reactions to cephalosporins, penicillins, or other drugs. Use with caution in patients with history of gastrointestinal disease, particularly colitis. Prolonged use may result in overgrowth of nonsusceptible organisms; if superinfection occurs during therapy, appropriate measures should be taken. Keftab should be administered with caution in patients with significantly impaired renal function, with dosage adjustments based on creatinine clearance. In patients with both renal and hepatic impairment, close clinical monitoring is advised. False positive reactions for glucose in the urine may occur with Benedict’s or Fehling’s solutions but not with enzyme-based tests. Positive direct Coombs tests have been reported during treatment with cephalosporin antibiotics.
Contraindications
Keftab is contraindicated in patients with known hypersensitivity to cephalexin or any component of the formulation. Cross-hypersensitivity may occur in patients allergic to penicillins; cephalosporins should be used with caution in penicillin-allergic patients. Contraindicated in patients with previous severe hypersensitivity reactions (e.g., anaphylaxis) to any cephalosporin. Not recommended for patients with known phenylketonuria, as some formulations may contain phenylalanine. Should not be used for the treatment of viral infections, including the common cold or flu, as antibiotics are ineffective against viruses.
Possible side effect
The most common adverse reactions associated with Keftab involve the gastrointestinal system, including diarrhea (occurring in up to 5% of patients), nausea, vomiting, abdominal pain, and dyspepsia. Hypersensitivity reactions manifested by skin rash, urticaria, angioedema, and rarely, anaphylaxis may occur. Other reported side effects include genital and anal pruritus, genital moniliasis, vaginitis and vaginal discharge, dizziness, fatigue, and headache. Transient elevations in hepatic enzymes have been observed. As with other broad-spectrum antibiotics, pseudomembranous colitis has been reported with the use of cephalexin. Hematologic effects including neutropenia, thrombocytopenia, and eosinophilia have been reported rarely.
Drug interaction
Probenecid may decrease renal tubular secretion of cephalexin, resulting in increased and prolonged blood levels. Concomitant use with potent diuretics (e.g., furosemide, ethacrynic acid) may increase the risk of nephrotoxicity. Administration with metformin may decrease metformin clearance and increase metformin blood levels. Cephalexin may reduce the efficacy of oral contraceptives; additional contraceptive methods are recommended during therapy. False positive urine glucose determinations may occur with reducing substance methods (e.g., Clinitestยฎ). The presence of cephalexin in the urine may interfere with some laboratory tests for glycosuria and proteinuria.
Missed dose
If a dose of Keftab is missed, it should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not double the dose to make up for a missed one. Maintaining consistent antibiotic blood levels is important for therapeutic efficacy, so patients should be instructed to adhere to the prescribed dosing schedule as closely as possible. Setting reminders or using pill organizers can help prevent missed doses during the treatment course.
Overdose
Symptoms of cephalexin overdose may include nausea, vomiting, epigastric distress, diarrhea, and hematuria. In the event of overdose, general supportive care is recommended, including gastric lavage if ingestion was recent. Hemodialysis may aid in the removal of cephalexin from the body, particularly in patients with renal impairment. Management should focus on maintaining hydration, electrolyte balance, and other symptomatic treatments as necessary. There is no specific antidote for cephalexin overdose. Serum cephalexin levels are not widely available for clinical monitoring, so treatment remains primarily supportive.
Storage
Store Keftab tablets at controlled room temperature between 20ยฐC to 25ยฐC (68ยฐF to 77ยฐF), with excursions permitted between 15ยฐC to 30ยฐC (59ยฐF to 86ยฐF). Keep in the original container, tightly closed, and protect from light and moisture. Do not store in the bathroom or near sinks. Keep all medications out of reach of children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard expired or no longer needed medication through medication take-back programs or according to FDA guidelines.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Keftab is a prescription medication that should be used only under the supervision of a qualified healthcare professional. The prescribing physician should be consulted for diagnosis and treatment decisions. Individual patient responses to medication may vary. Never initiate, discontinue, or change dosage of any medication without consulting your healthcare provider. Report any adverse reactions to your physician immediately.
Reviews
Clinical studies have demonstrated cephalexin’s efficacy with bacterial eradication rates exceeding 85% for susceptible infections in compliant patients. Healthcare providers report satisfactory clinical outcomes in appropriately selected patients, particularly for skin and soft tissue infections and uncomplicated urinary tract infections. Some patients note gastrointestinal side effects as the most common reason for discontinuation. The twice-daily dosing regimen for certain indications is frequently cited as improving adherence compared to more frequent dosing schedules. Resistance patterns have evolved over time, necessitating ongoing susceptibility testing to ensure appropriate use.