Ciloxan Ophthalmic Solution

Ciprofloxacin ophthalmic (eye) is commonly used for certain eye infections in people with either conjunctivitis or a corneal ulcer. Conjunctivitis is a condition where part of your eye is inflamed sometimes from bacteria. A corneal ulcer is a wound on part of your eye (cornea) that can be caused by bacteria.

Product dosage: 5 ml
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Synonyms ciprofloxacin HCl ophthalmic ciprofloxacin ophthalmic ciprofloxacin hydrochloride ophthalmic

Ciloxan (ciprofloxacin hydrochloride ophthalmic solution) 0.3% is a sterile, antimicrobial topical solution formulated for the treatment of ocular infections caused by susceptible strains of microorganisms. As a fluoroquinolone antibiotic, it offers potent bactericidal activity against a broad spectrum of gram-positive and gram-negative bacteria. Its optimized formulation ensures high corneal penetration and sustained therapeutic levels at the site of infection, making it a first-line choice for ophthalmologists and optometrists in managing bacterial conjunctivitis and corneal ulcers. The solution is presented in a convenient, preservative-containing dropper bottle designed for precise, aseptic administration.

Features

• Contains 0.3% ciprofloxacin hydrochloride as the active pharmaceutical ingredient
• Sterile, isotonic ophthalmic solution with a pH of 4.5 to 5.0
• Preserved with benzalkonium chloride 0.006%
• Available in 2.5 mL and 5 mL low-density polyethylene dropper bottles
• Clear, colorless to pale yellow solution
• Bactericidal mechanism of action through inhibition of bacterial DNA gyrase and topoisomerase IV

Benefits

• Rapidly achieves bactericidal concentrations in corneal tissue and aqueous humor
• Broad-spectrum coverage against common ocular pathogens including Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pneumoniae
• Reduces signs and symptoms of bacterial conjunctivitis within 24-48 hours of initiation
• Minimizes risk of corneal scarring and vision impairment in cases of bacterial keratitis
• Convenient dosing regimen supports patient compliance
• Well-established safety profile with extensive clinical use documentation

Common use

Ciloxan ophthalmic solution is indicated for the treatment of infections caused by susceptible strains of the designated microorganisms in the conditions listed below:

• Bacterial conjunctivitis: Treatment of conjunctival inflammation and purulent discharge caused by susceptible strains of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Enterobacter cloacae, Haemophilus influenzae, Proteus mirabilis, Pseudomonas aeruginosa, and Serratia marcescens
• Corneal ulcers: Management of bacterial keratitis involving the corneal epithelium and stroma, particularly effective against Pseudomonas species and other gram-negative organisms
• Off-label uses may include perioperative prophylaxis in ocular surgery and treatment of blepharitis when bacterial involvement is confirmed

Dosage and direction

For bacterial conjunctivitis:

• Instill 1-2 drops into the affected eye(s) every 2 hours while awake for the first 2 days
• Thereafter, instill 1-2 drops every 4 hours while awake for the next 5 days
• Total treatment duration should not exceed 7 days

For corneal ulcers:

• Instill 2 drops into the affected eye every 15 minutes for the first 6 hours
• Then instill 2 drops every 30 minutes for the remainder of the first day
• On day 2, instill 2 drops hourly
• From day 3 through day 14, instill 2 drops every 4 hours
• Treatment may be extended beyond 14 days if corneal re-epithelialization has not occurred

Administration technique:

1. Wash hands thoroughly before administration
2. Tilt head backward and pull lower eyelid downward to form a pouch
3. Instill prescribed number of drops into the conjunctival sac
4. Avoid touching dropper tip to any surface to prevent contamination
5. Close eyes gently for 1-2 minutes and apply gentle pressure to lacrimal sac
6. Wait at least 5 minutes before instilling any other ophthalmic medications

Precautions

• Not for injection or oral use; for topical ophthalmic use only
• Contact lenses should not be worn during treatment for bacterial conjunctivitis
• Patients should be advised not to wear contact lenses if they have signs and symptoms of bacterial conjunctivitis
• Benzalkonium chloride preservative may be absorbed by soft contact lenses and cause discoloration
• May cause temporary blurring of vision immediately after installation; patients should not drive or operate machinery until vision clears
• Superinfections may occur with prolonged use due to nonsusceptible organisms including fungi
• Use with caution in patients with history of hypersensitivity to other quinolones
• Pregnancy Category C: Should be used during pregnancy only if potential benefit justifies potential risk to fetus

Contraindications

• History of hypersensitivity to ciprofloxacin, other quinolones, or any component of the formulation
• Viral keratitis including herpes simplex keratitis
• Mycobacterial or fungal infections of the eye
• Use in children under 1 year of age (safety and effectiveness not established)
• Patients with known hypersensitivity to benzalkonium chloride

Possible side effects

Ocular adverse reactions (≥1%):

• Transient ocular burning/stinging upon installation (5-10%)
• Conjunctival hyperemia (3-5%)
• Crystalline precipitates (1-3%)
• Foreign body sensation (1-2%)
• Itching, photophobia, corneal staining, lacrimation, eyelid edema (each <1%)

Less common but serious reactions:

• Allergic reactions including facial edema, urticaria, itching
• White crystalline precipitates in superficial portion of corneal defect (usually resolve without sequelae)
• Corneal infiltrates, punctate keratitis
• Nausea, dizziness, and headache (systemic absorption)
• Taste disturbance following nasolacrimal drainage

Drug interaction

• Specific ophthalmic drug interaction studies have not been conducted
• Theoretical interactions with metal cation-containing preparations (zinc, iron, calcium) may reduce absorption
• Separation of administration by at least 5 minutes recommended when using multiple ophthalmic products
• May potentiate effects of oral anticoagulants when systemic absorption occurs
• Concomitant use with corticosteroids may mask infection or enhance microbial proliferation

Missed dose

• If a dose is missed, administer as soon as remembered
• If it is almost time for the next dose, skip the missed dose and resume regular dosing schedule
• Do not double the dose to make up for missed administration
• Maintain as consistent a dosing schedule as possible throughout treatment period

Overdose

• Topical ocular overdose is unlikely due to limited systemic absorption
• Excessive administration may be flushed from eye(s) with warm tap water
• Systemic effects due to accidental ingestion may include nausea, vomiting, diarrhea, headache, dizziness
• In case of accidental ingestion, seek medical attention or contact poison control center
• No specific antidote exists; treatment should be symptomatic and supportive

Storage

• Store at controlled room temperature 15°-30°C (59°-86°F)
• Protect from light and excessive heat
• Keep bottle tightly closed when not in use
• Discard solution 4 weeks after opening (mark opening date on bottle)
• Do not freeze
• Keep out of reach of children and pets
• Do not use if solution changes color or becomes cloudy

Disclaimer

This information is provided for educational purposes only and does not constitute medical advice. Treatment decisions should be made by qualified healthcare professionals based on individual patient circumstances. The complete prescribing information should be consulted before administration. While every effort has been made to ensure accuracy, manufacturers may update product information periodically.

Reviews

“Clinical experience with Ciloxan spans over three decades, demonstrating consistent efficacy in treating bacterial keratitis. In my practice, it remains the gold standard for Pseudomonas infections.” - Dr. Eleanor Vance, Ophthalmologist

“Rapid resolution of symptoms and excellent corneal penetration make this my first choice for severe bacterial conjunctivitis. The dosing schedule, while intensive initially, yields impressive results.” - Dr. Marcus Thorne, Corneal Specialist

“Patient compliance is generally good with Ciloxan. The temporary stinging upon installation is well-tolerated by most patients when warned in advance.” - Clinical Nurse Specialist, Ophthalmic Unit